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Intermittent fasting activates many of the same longevity pathways that supplements target — autophagy, AMPK, sirtuins, and NAD+. Learn how to combine fasting with your supplement stack for maximum synergy, and which supplements to take when.

Learn how autophagy works, why it declines with age, and the three proven ways to activate it: fasting, exercise, and targeted supplements like spermidine.

You're probably already eating spermidine every day — in your wheat bread, aged parmesan, or morning mushrooms. This naturally occurring compound is one of the most scientifically credible longevity tools of the decade, triggering the cellular self-cleaning process that slows ageing from the inside out.

Your gut contains 100 trillion microorganisms that influence everything from digestion to mood. Here's what probiotics, prebiotics and postbiotics actually do — and what the evidence says about supplements.